The Macaulay Museum of Dental History houses an impressive collection of dental memorabilia, including a dental office of circa 1900; a series of dental chairs spanning many years, including a child's chair; an instrument made by Paul Revere for Dr. Josiah Flagg, the first American-born, full-time dentist; and an itinerate dentist's chest of the Civil War era.

The mission of the Waring Historical Library's Macaulay Museum of Dental History is to serve the Library and University as the repository for information and resources about the history of dentistry and dental practitioners.

As funding and space permit, materials are acquired for the Macaulay Museum of Dental History by donation or purchase with the collection focus of South Carolina and southeastern dentists, or the history of dental medicine in South Carolina or the southeast.

Collecting this material was the lifelong avocation of Dr. Neill Macaulay, a Columbia dentist and long-time supporter of the Medical University. The collection was given to MUSC as part of the Bi-Centennial celebration in 1976.